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Image Search Results
Journal: bioRxiv
Article Title: Metabolic and Thermal Cues Shape IL-6 Responses and Disease Tolerance Mechanisms in Severe Malaria
doi: 10.64898/2026.04.14.718305
Figure Lengend Snippet: Estimated marginal means (EMMs) of IL‐6 secretion from PBn-parasite co‐cultures under factorial combinations of temperature (37°C, 40°C), pipecolic acid (PA; present/absent), lysophosphatidylcholine (LPC; replete/depleted), and parasite exposure (parasite vs no parasite). Panels A and B show the effects of LPC depletion and repletion, respectively. Panel C shows the effect of parasite exposure independent of metabolic conditions. IL‐6 production is highest under febrile temperature (40°C) when PA is present, and LPC is available. Parasite exposure modestly increases IL‐6 across conditions, but metabolic context remains the dominant determinant of IL‐6 output.
Article Snippet: IL-6 concentrations in co-culture supernatants were quantified using the
Techniques:
Journal: bioRxiv
Article Title: Metabolic and Thermal Cues Shape IL-6 Responses and Disease Tolerance Mechanisms in Severe Malaria
doi: 10.64898/2026.04.14.718305
Figure Lengend Snippet: Interaction plot showing estimated marginal means (EMMs) of IL‐6 secretion across factorial combinations of temperature (37°C, 40°C), pipecolic acid (PA; absent/present), and lysophosphatidylcholine (LPC; depleted/replete). Lines represent model‐adjusted means. IL‐6 production increases under febrile temperature (40°C), particularly when PA is present, and LPC is replete. Panel A: LPC‐depleted conditions. Panel B: LPC‐replete conditions.
Article Snippet: IL-6 concentrations in co-culture supernatants were quantified using the
Techniques: